Noriega-Makarskyy DT, Realbuto E, Kaylor A, Osiecki L, Essa A, Yu D, Illmann C, Mathews CA, & Scharf JM. Relationships between the menstrual cycle and neuropsychiatric and physical symptoms in females with Tourette syndrome. In press. Front. Neurol. 16:1500766. doi:10.3389/fneur.2025.1500766
Dy-Hollins ME, Chibnik LB, Tracy NA, Osiecki L, … & Scharf JM. Sex Differences in Natural History and Health Outcomes Among Individuals With Tic Disorders. Neurology. 2025;104(3):e210249. doi:10.1212/WNL.0000000000210249
Ivankovic F, Johnson S, Shen J, Scharf JM, Mathews CA. Optimization of self- or parent-reported psychiatric phenotypes in longitudinal studies. J Child Psychol Psychiatry. 2025;66(2):253-265. doi:10.1111/jcpp.14054
Miller-Fleming TW, Allos A, Gantz E, Yu D, … Scharf JM, et al. Developing a phenotype risk score for tic disorders in a large, clinical biobank. Transl Psychiatry. 2024;14(1):311. Published 2024 Jul 28. doi:10.1038/s41398-024-03011-w
Tsetsos F, Topaloudi A, Jain P, … Yu D, … Scharf JM, et al. Genome-Wide Association Study Points to Novel Locus for Gilles de la Tourette Syndrome. Biol Psychiatry. 2024;96(2):114-124. doi:10.1016/j.biopsych.2023.01.023
Strom NI, Gerring ZF, Galimberti M, Yu D, … Osiecki L, … Scharf JM, et al. Genome-wide association study identifies 30 obsessive-compulsive disorder associated loci. Preprint. medRxiv. 2024;2024.03.13.24304161. Published 2024 Mar 13. doi:10.1101/2024.03.13.24304161
Armstrong-Javors A, Realbuto E, Dy-Hollins ME, Scharf JM. Increase in Functional Tic Presentations in Sexual Orientation and Gender Identity Minority Youth During Coronavirus Disease 2019. Pediatr Neurol. 2024;155:182-186. doi:10.1016/j.pediatrneurol.2024.03.027
Dy-Hollins ME, Carr SJ, Essa A, Osiecki L, … Scharf JM. The Challenge of Examining Social Determinants of Health in People Living With Tourette Syndrome. Pediatr Neurol. 2024;155:55-61. doi:10.1016/j.pediatrneurol.2024.02.008
Tanev KS, Camprodon JA, Caplan DN, … Scharf JM, et al. Telemedicine-Based Cognitive Examinations During COVID-19 and Beyond: Perspective of the Massachusetts General Hospital Behavioral Neurology & Neuropsychiatry Group. J Neuropsychiatry Clin Neurosci. 2024;36(2):87-100. doi:10.1176/appi.neuropsych.20220154
Kanaan AS, Yu D, Metere R, … Scharf JM, et al. Convergent imaging-transcriptomic evidence for disturbed iron homeostasis in Gilles de la Tourette syndrome. Neurobiol Dis. 2023;185:106252. doi:10.1016/j.nbd.2023.106252
Jain P, Miller-Fleming T, Topaloudi A, Yu D, … Scharf JM, et al. Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome. Transl Psychiatry. 2023;13(1):69. Published 2023 Feb 23. doi:10.1038/s41398-023-02341-5
Yu D, Scharf JM. Direct and Indirect Effects in Trio Studies: You Don’t Know What You’re Missing. Biol Psychiatry. 2023;93(1):6-7. doi:10.1016/j.biopsych.2022.10.004
Yang K, Essa A, Noriega D, Yu D, Osiecki L, Gauvin CA, Illman C, … Scharf JM. Relationship between adverse childhood experiences and symptom severity in adult men with Tourette Syndrome. J Psychiatr Res. 2022;155:252-259. doi:10.1016/j.jpsychires.2022.08.024
Grant JE, Peris TS, Ricketts EJ, … Scharf JM, et al. Reward processing in trichotillomania and skin picking disorder. Brain Imaging Behav. 2022;16(2):547-556. doi:10.1007/s11682-021-00533-5
Halvorsen M, Szatkiewicz J, Mudgal P, Yu D, … Scharf JM, et al. Elevated common variant genetic risk for tourette syndrome in a densely-affected pedigree. Mol Psychiatry. 2021;26(12):7522-7529. doi:10.1038/s41380-021-01277-w
Abdulkadir M, Yu D, Osiecki L, … Scharf JM, et al. Investigation of gene-environment interactions in relation to tic severity. J Neural Transm (Vienna). 2021;128(11):1757-1765. doi:10.1007/s00702-021-02396-y
Zhou D, Yu D, Scharf JM, et al. Contextualizing genetic risk score for disease screening and rare variant discovery. Nat Commun. 2021;12(1):4418. Published 2021 Jul 20. doi:10.1038/s41467-021-24387-z
Claudio-Campos K, Stevens D, Koo SW, … Greenberg E, … Illmann C, Ivankovic F, … Osiecki L, … Scharf JM, et al. Is Persistent Motor or Vocal Tic Disorder a Milder Form of Tourette Syndrome? Mov Disord. 2021;36(8):1899-1910. doi:10.1002/mds.28593
Camprodon JA, Chou T, Testo AA, Deckersbach T, Scharf JM, Dougherty DD. Case Report: Deep Brain Stimulation to the Ventral Internal Capsule/Ventral Striatum Induces Repeated Transient Episodes of Voltage-Dependent Tourette-Like Behaviors. Front Hum Neurosci. 2021;14:590379. Published 2021 Jan 25. doi:10.3389/fnhum.2020.590379
Tsetsos F, Yu D, Sul JH, … Illmann C, Osiecki L, … Greenberg E, … Scharf JM, et al. Synaptic processes and immune-related pathways implicated in Tourette syndrome. Transl Psychiatry. 2021;11(1):56. Published 2021 Jan 18. doi:10.1038/s41398-020-01082-z
Grant JE, Peris TS, Ricketts EJ, … Scharf JM, et al. Identifying subtypes of trichotillomania (hair pulling disorder) and excoriation (skin picking) disorder using mixture modeling in a multicenter sample. J Psychiatr Res. 2021;137:603-612. doi:10.1016/j.jpsychires.2020.11.001
Bralten J, Widomska J, Witte W, Yu D, … Scharf JM, et al. Shared genetic etiology between obsessive-compulsive disorder, obsessive-compulsive symptoms in the population, and insulin signaling. Transl Psychiatry. 2020;10(1):121. Published 2020 Apr 27. doi:10.1038/s41398-020-0793-y
Yilmaz Z, Halvorsen M, Bryois J, Yu D, … Scharf JM, et al. Examination of the shared genetic basis of anorexia nervosa and obsessive-compulsive disorder. Mol Psychiatry. 2020;25(9):2036-2046. doi:10.1038/s41380-018-0115-4
Rose O, Hartmann A, Worbe Y, Scharf JM, Black KJ. Tourette syndrome research highlights from 2018. F1000Res. 2019;8:988. Published 2019 Jul 1. doi:10.12688/f1000research.19542.1
Mufford M, Cheung J, Jahanshad N, … Scharf JM, et al. Concordance of genetic variation that increases risk for tourette syndrome and that influences its underlying neurocircuitry. Transl Psychiatry. 2019;9(1):120. Published 2019 Mar 22. doi:10.1038/s41398-019-0452-3
Yu D, Sul JH, Tsetsos F, … Illmann C, Osiecki L, … Greenberg E, … & Scharf JM. Interrogating the Genetic Determinants of Tourette’s Syndrome and Other Tic Disorders Through Genome-Wide Association Studies. Am J Psychiatry. 2019;176(3):217-227. doi:10.1176/appi.ajp.2018.18070857
Abdulkadir M, Mathews CA, Scharf JM, Yu D, et al. Polygenic Risk Scores Derived From a Tourette Syndrome Genome-wide Association Study Predict Presence of Tics in the Avon Longitudinal Study of Parents and Children Cohort. Biol Psychiatry. 2019;85(4):298-304. doi:10.1016/j.biopsych.2018.09.011
Wang S, Mandell JD, Kumar Y, … Yu D, … Scharf JM, et al. De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis. Cell Rep. 2018;25(12):3544. doi:10.1016/j.celrep.2018.12.024
Wang S, Mandell JD, Kumar Y, … Yu D, … Scharf JM, et al. De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis [published correction appears in Cell Rep. 2018 Dec 18;25(12):3544. doi: 10.1016/j.celrep.2018.12.024.]. Cell Rep. 2018;24(13):3441-3454.e12. doi:10.1016/j.celrep.2018.08.082
Perez DL, Keshavan MS, Scharf JM, Boes AD, Price BH. Bridging the Great Divide: What Can Neurology Learn From Psychiatry?. J Neuropsychiatry Clin Neurosci. 2018;30(4):271-278. doi:10.1176/appi.neuropsych.17100200
Greenberg E, Tung ES, Gauvin C, Osiecki L, Yang KG, … Essa A, Illmann C, … & Scharf JM. Prevalence and predictors of hair pulling disorder and excoriation disorder in Tourette syndrome. Eur Child Adolesc Psychiatry. 2018;27(5):569-579. doi:10.1007/s00787-017-1074-z
Hirschtritt ME, Darrow SM, Illmann C, Osiecki L, … Greenberg E, … Yu D, McGrath LM, … Lee PC, … Scharf JM, et al. Genetic and phenotypic overlap of specific obsessive-compulsive and attention-deficit/hyperactive subtypes with Tourette syndrome. Psychol Med. 2018;48(2):279-293. doi:10.1017/S0033291717001672
Greenberg E, Grant JE, Curley EE, … Scharf JM, et al. Predictors of comorbid eating disorders and association with other obsessive-compulsive spectrum disorders in trichotillomania. Compr Psychiatry. 2017;78:1-8. doi:10.1016/j.comppsych.2017.06.008
Darrow SM, Grados M, Sandor P, … Illmann C, Osiecki L, … Greenberg E, … Lee PC, … Scharf JM, et al. Autism Spectrum Symptoms in a Tourette’s Disorder Sample. J Am Acad Child Adolesc Psychiatry. 2017;56(7):610-617.e1. doi:10.1016/j.jaac.2017.05.002
Huang AY, Yu D, Davis LK, … Osiecki L, … McGrath LM, Illmann C, … Scharf JM, et al. Rare Copy Number Variants in NRXN1 and CNTN6 Increase Risk for Tourette Syndrome. Neuron. 2017;94(6):1101-1111.e7. doi:10.1016/j.neuron.2017.06.010
Willsey AJ, Fernandez TV, Yu D, … Scharf JM, et al. De Novo Coding Variants Are Strongly Associated with Tourette Disorder. Neuron. 2017;94(3):486-499.e9. doi:10.1016/j.neuron.2017.04.024
Leivonen S, Scharf JM, Mathews CA, et al. Parental Psychopathology and Tourette Syndrome/Chronic Tic Disorder in Offspring: A Nationwide Case-Control Study. J Am Acad Child Adolesc Psychiatry. 2017;56(4):297-303.e4. doi:10.1016/j.jaac.2017.01.009
Robertson MM, Eapen V, Singer HS, … Scharf JM, et al. Gilles de la Tourette syndrome. Nat Rev Dis Primers. 2017;3:16097. Published 2017 Feb 2. doi:10.1038/nrdp.2016.97
Darrow SM, Hirschtritt ME, Davis LK, Illmann C, Osiecki L, … Greenberg E, … Yu D, McGrath LM, … Lee PC, … Scharf JM, et al. Identification of Two Heritable Cross-Disorder Endophenotypes for Tourette Syndrome. Am J Psychiatry. 2017;174(4):387-396. doi:10.1176/appi.ajp.2016.16020240
Keuthen NJ, Curley EE, Scharf JM, … Greenberg E, et al. Predictors of comorbid obsessive-compulsive disorder and skin-picking disorder in trichotillomania. Ann Clin Psychiatry. 2016;28(4):280-288.
Forde NJ, Kanaan AS, Widomska J, … Scharf JM, et al. TS-EUROTRAIN: A European-Wide Investigation and Training Network on the Etiology and Pathophysiology of Gilles de la Tourette Syndrome. Front Neurosci. 2016;10:384. Published 2016 Aug 23. doi:10.3389/fnins.2016.00384
Georgitsi M, Willsey AJ, Mathews CA, State M, Scharf JM, Paschou P. The Genetic Etiology of Tourette Syndrome: Large-Scale Collaborative Efforts on the Precipice of Discovery. Front Neurosci. 2016;10:351. Published 2016 Aug 3. doi:10.3389/fnins.2016.00351
Lek M, Karczewski KJ, Minikel EV, … Yu D, … Scharf JM, et al. Analysis of protein-coding genetic variation in 60,706 humans. Nature. 2016;536(7616):285-291. doi:10.1038/nature19057
Hirschtritt ME, Dy ME, Yang KG, Scharf JM. Child Neurology: Diagnosis and treatment of Tourette syndrome. Neurology. 2016;87(7):e65-e67. doi:10.1212/WNL.0000000000002977
Lizano P, Popat-Jain A, Scharf JM, et al. Challenges in Managing Treatment-Refractory Obsessive-Compulsive Disorder and Tourette’s Syndrome. Harv Rev Psychiatry. 2016;24(4):294-301. doi:10.1097/HRP.0000000000000121
Hirschtritt ME, Darrow SM, Illmann C, Osiecki L, … Greenberg E, … Yu D, McGrath LM, … Lee PC, … Scharf JM, et al. Social disinhibition is a heritable subphenotype of tics in Tourette syndrome. Neurology. 2016;87(5):497-504. doi:10.1212/WNL.0000000000002910
Scharf JM. Parity in Tourette Syndrome: Reproducible Risk Factors for an Underrecognized Neurodevelopmental Disorder. J Pediatr. 2016;171:17-19. doi:10.1016/j.jpeds.2015.12.048
Ben-Shlomo Y, Scharf JM, Miller LL, Mathews CA. Parental mood during pregnancy and post-natally is associated with offspring risk of Tourette syndrome or chronic tics: prospective data from the Avon Longitudinal Study of Parents and Children (ALSPAC). Eur Child Adolesc Psychiatry. 2016;25(4):373-381. doi:10.1007/s00787-015-0742-0
